Luke wrote:
"Shoot the Tubes!" - Sewer Shark
How could I forget Sewer Shark! Ghost is full of memorable lines like 'I love the smell of the sewers in the morning'
Others that I can think of include:
'Greetings Mortal.. are you ready to Die?' - Hexen
Pretty much anything Washington says - HotD:Overkill
I realize that I'm breaking the rules of my own thread with those though.
@Ziggy - I know that the majority of gaming history has nothing to offer in the quotes department other than funny one liners, but surely since the PS2 era there have been a whole load of story driven games with increasingly more developed characterizations in them. Surely some of these characters have moved some of us at some point?