What were some plot lines in a game you played that was able to strike an emotional chord in you? Maybe even made you cry? Come on, your game made you cry and that's ok.

For me, it would have to be:
The crying Sasquatch in Red Dead Undead
The first half of Prey, especially when you see your grandfather die!

We had a thread like this not too long ago. You'll see more there.
viewtopic.php?f=44&t=31907&hilit=shed+a+tear

Since that thread, To The Moon really worked a number on my tear ducts.

Oh nice thanks for the heads up!